(Download) "Heteroaromatic Lipoxin A4 Analogues" by Colm Duffy # eBook PDF Kindle ePub Free
eBook details
- Title: Heteroaromatic Lipoxin A4 Analogues
- Author : Colm Duffy
- Release Date : January 10, 2012
- Genre: Chemistry,Books,Science & Nature,Life Sciences,
- Pages : * pages
- Size : 2243 KB
Description
In this thesis Colm Duffy reviews the chemistry and biology of stable lipoxin analogues. Colm has prepared for the first time ever a pyridine-containing LXA4 analogue in enantiomerically pure form. Biological evaluation determined that both epimers at the benzylic position suppress key cytokines known to be involved in inflammatory disease, with the (R)-epimer proving most efficacious. Moreover the author developed an excellent route to a related thiophene-containing analogue that also showed interesting biological activity. Both routes have inspired further work in the synthesis of further heteroaromatic analogues for biological evaluation.
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